The LV Pall Centrasette TFF Cassette Holder is an essential, compact benchtop system designed for reliable and efficient tangential flow filtration at the laboratory scale. Engineered to hold Pall’s industry-standard Centramate or Centrasette membrane cassettes, this holder is the cornerstone for developing and optimizing purification processes for proteins, vaccines, nucleic acids, and other valuable biomolecules.
Perfect for process development, feasibility studies, and small-volume production, the Centrasette holder enables precise control over key TFF operations, including concentration, diafiltration, and clarification.
Key Features & Benefits:
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Scalable Process Development: Generate robust, scalable data from milligram to gram quantities. Processes developed with the LV Centrasette holder translate predictably to larger Pall production-scale TFF systems.
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Compact & Efficient Design: The low-volume (“LV”) design minimizes hold-up volume, maximizing product recovery of precious samples—a critical factor in early-stage R&D and biomanufacturing.
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Compatibility & Versatility: Specifically designed to securely house Pall Centramate 5-inch (13 cm) cassettes (1, 2, or 3-channel configurations). Compatible with a wide range of Pellicon® and Omega™ ultrafiltration (UF) and microfiltration (MF) membranes to suit your specific molecular weight cut-off (MWCO) and process requirements.
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Robust & Reliable Construction: Manufactured from high-quality, chemically resistant materials suitable for a broad pH range and common buffer systems. Features secure gasketing and even flow distribution to ensure consistent performance and minimize leakage.
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Ease of Use: Designed for straightforward cassette insertion, sealing, and connection to your pump and feed system. Simplifies system setup, operation, and cleaning between runs.
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Ideal Applications:
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Protein and antibody concentration/buffer exchange
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Vaccine purification
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Viral vector and nucleic acid processing
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Cell harvest and clarification
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Process optimization and scale-up studies
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Technical Specifications:
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Holder Type: Benchtop, Low-Volume (LV) Cassette Holder
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Cassette Compatibility: Pall Centramate / Centrasette 5-inch (13 cm) cassettes
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Typical Configuration: Accommodates a single cassette
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Ports: Standard luer or hose barb fittings for easy tubing connection (specify required connection type)
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Materials: Chemically resistant polymers, silicone gaskets
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Operation Mode: Tangential Flow Filtration (TFF) / Crossflow Filtration
Why Choose the Pall Centrasette TFF Holder?
The LV Pall Centrasette Holder is more than just hardware; it’s part of Pall’s trusted TFF technology platform. By choosing Pall, you benefit from decades of expertise in separation science, extensive application support, and a seamless path from lab-scale discovery to full commercial manufacturing. It is the preferred choice for scientists and process engineers who demand reliability, scalability, and precision in their downstream purification workflows.
